Synthetic hGRF(1–29) analogue

Sermorelin

Also catalogued as GRF(1–29) amide, GHRH(1–29).

CAS number: 86168-78-7
Molecular formula: C149H246N44O42S
Molecular weight: 3357.93 g/mol
PubChem CID: —

Identity

CAS number: 86168-78-7
Molecular formula: C149H246N44O42S
Molecular weight: 3357.93 g/mol
Residues: 29

Sequence: YADAIFTNSYRKVLGQLSARKLLQDIMSR

The native sequence, carried as a C-terminal amide.

What it is

Sermorelin is the first twenty-nine residues of human growth-hormone-releasing factor, made as a C-terminal amide. The amino-acid sequence is identical to the amino-terminal portion of the native 44-residue hormone; nothing is substituted.

The parent factor was isolated from a human pancreatic islet tumour and characterised in 1982, and the 1–29 fragment was shown in that period to retain the full activity of the longer sequence in vitro. Sermorelin is produced by chemical synthesis.

Regulatory status

Sermorelin was the active ingredient of a prescription product formerly approved by the U.S. FDA and withdrawn from the market in 2008. The research material listed here is not that product and is not a drug.

Primary literature

Rivier J, Spiess J, Thorner M, Vale W. Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour. Nature 1982;300(5889):276–278.
doi:10.1038/300276a0

Citation titles are reproduced verbatim from the journal record. A citation documents the molecule's published identity and history; it is not a claim about the material sold here.

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What it is

Primary literature

Citation titles are reproduced verbatim from the journal record. A citation documents the molecule's published identity and history; it is not a claim about the material sold here.