Synthetic heptapeptide

Semax

Also catalogued as ACTH(4–7)PGP.

CAS number: 80714-61-0
Molecular formula: C37H51N9O10S
Molecular weight: 813.92 g/mol
PubChem CID: —

Identity

CAS number: 80714-61-0
Molecular formula: C37H51N9O10S
Molecular weight: 813.92 g/mol
Residues: 7

Sequence: MEHFPGP

What it is

Semax is a synthetic peptide of seven amino-acid residues: methionine, glutamate, histidine, phenylalanine, proline, glycine, proline. Its first four residues reproduce residues 4 to 7 of adrenocorticotropic hormone; the proline-glycine-proline tail replaces the arginine-tryptophan-glycine of the natural ACTH(4–10) fragment.

The substitution removes the corticotropic portion of the parent sequence and slows cleavage by plasma peptidases. It was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences.

Regulatory status

Semax is not an approved drug in the United States or the European Union. It has been registered in Russia; the research material listed here is not that product.

Primary literature

Dolotov OV, Karpenko EA, Inozemtseva LS, et al. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Research 2006;1117(1):54–60.
PMID 16996037

Citation titles are reproduced verbatim from the journal record. A citation documents the molecule's published identity and history; it is not a claim about the material sold here.

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