Synthetic heptapeptide

Selank

Also catalogued as TP-7.

CAS number: 129954-34-3
Molecular formula: C33H57N11O9
Molecular weight: 751.87 g/mol
PubChem CID: —

Identity

CAS number: 129954-34-3
Molecular formula: C33H57N11O9
Molecular weight: 751.87 g/mol
Residues: 7

Sequence: TKPRPGP

What it is

Selank is a synthetic peptide of seven amino-acid residues: threonine, lysine, proline, arginine, proline, glycine, proline. Its first four residues are the sequence of tuftsin, a tetrapeptide fragment of the immunoglobulin G heavy chain; the proline-glycine-proline tail is a synthetic addition that slows cleavage by aminopeptidases.

It was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences and is produced by chemical synthesis.

Regulatory status

Selank is not an approved drug in the United States or the European Union. It has been registered in Russia; the research material listed here is not that product.

Primary literature

Volkova A, Shadrina M, Kolomin T, et al. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Frontiers in Pharmacology 2016;7:31.
doi:10.3389/fphar.2016.00031

Citation titles are reproduced verbatim from the journal record. A citation documents the molecule's published identity and history; it is not a claim about the material sold here.

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