Spadin-derived heptapeptide

PE-22-28

Also catalogued as PE 22-28, Spadin (22-28).

CAS number: 1801959-12-5
Molecular formula: C35H55N11O9
Molecular weight: 773.89 g/mol
PubChem CID: —

Identity

CAS number: 1801959-12-5
Molecular formula: C35H55N11O9
Molecular weight: 773.89 g/mol
Residues: 7

Sequence: GVSWGLR

Seven residues with a free acid C-terminus and no modified positions, so the one-letter string is the whole structure. The name records where the fragment sits: residues 22 to 28 of spadin.

What it is

PE-22-28 is a synthetic heptapeptide corresponding to residues 22 through 28 of spadin. Spadin is itself a fragment — a 17-residue peptide released from the propeptide of sortilin, the sorting receptor encoded by the SORT1 gene, when that propeptide is cleaved during maturation.

The shortened fragment was described by Djillani and colleagues in 2017, among a set of spadin analogues prepared to test which part of the parent sequence carried its activity. It is produced by solid-phase synthesis.

Regulatory status

PE-22-28 is a research peptide. It is not an approved drug in any jurisdiction.

Primary literature

Djillani A, Pietri M, Moreno S, Heurteaux C, Mazella J, Borsotto M Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity. Frontiers in Pharmacology 2017;8:643.
PMID 28955242 doi:10.3389/fphar.2017.00643

Citation titles are reproduced verbatim from the journal record. A citation documents the molecule's published identity and history; it is not a claim about the material sold here.

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What it is

Primary literature

Citation titles are reproduced verbatim from the journal record. A citation documents the molecule's published identity and history; it is not a claim about the material sold here.