Mitochondrial-derived peptide

MOTS-c

Also catalogued as MOTS-c (human), Mitochondrial ORF of the 12S rRNA type-c.

CAS number: 1627580-64-6
Molecular formula: C101H152N28O22S2
Molecular weight: 2174.6 g/mol
PubChem CID: —

Identity

CAS number: 1627580-64-6
Molecular formula: C101H152N28O22S2
Molecular weight: 2174.6 g/mol
Residues: 16

Sequence: MRWQEMGYIFYPRKLR

What it is

MOTS-c is a peptide of sixteen amino-acid residues whose coding sequence lies within the mitochondrial 12S ribosomal RNA gene (MT-RNR1), one of the short open reading frames identified inside the mitochondrial genome. The name abbreviates "mitochondrial open reading frame of the 12S rRNA type-c".

The peptide was described in 2015 by Lee and colleagues, and is grouped in the literature with humanin and the SHLPs as a mitochondrial-derived peptide. The listed material is produced by chemical synthesis.

Regulatory status

MOTS-c is not an approved drug in any jurisdiction.

Primary literature

Lee C, Zeng J, Drew BG, et al. The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance. Cell Metabolism 2015;21(3):443–454.

Citation titles are reproduced verbatim from the journal record. A citation documents the molecule's published identity and history; it is not a claim about the material sold here.

Loading…