Synthetic hGRF(1–29) analogue

CJC-1295 w/o DAC

Also catalogued as Modified GRF(1–29), Mod GRF 1-29, CJC-1295 DAC-free.

CAS number: 863288-34-0
Molecular formula: C152H252N44O42
Molecular weight: 3367.90 g/mol
PubChem CID: —

Identity

CAS number: 863288-34-0
Molecular formula: C152H252N44O42
Molecular weight: 3367.90 g/mol
Residues: 29

The 29-residue human growth-hormone-releasing factor sequence carrying four substitutions, including a D-alanine at position 2; a plain one-letter rendering would not show the D-residue.

What it is

CJC-1295 without DAC is a synthetic analogue of the first twenty-nine residues of human growth-hormone-releasing factor, hGRF(1–29), carrying four amino-acid substitutions — D-alanine at position 2, glutamine at 8, alanine at 15, and leucine at 27 — that slow enzymatic cleavage of the peptide relative to the native sequence.

The parent sequence was characterised after growth-hormone-releasing factor was isolated from a human pancreatic islet tumour in 1982. The separate CJC-1295 molecule that carries a drug-affinity complex (DAC) is a different substance: this entry describes the material without it.

Regulatory status

CJC-1295 without DAC is not an approved drug in any jurisdiction.

Primary literature

Rivier J, Spiess J, Thorner M, Vale W. Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour. Nature 1982;300(5889):276–278.
doi:10.1038/300276a0

Citation titles are reproduced verbatim from the journal record. A citation documents the molecule's published identity and history; it is not a claim about the material sold here.

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What it is

Primary literature

Citation titles are reproduced verbatim from the journal record. A citation documents the molecule's published identity and history; it is not a claim about the material sold here.