Synthetic amylin analogue

Cagrilintide

Also catalogued as AM833, NN9838.

CAS number: 1415456-99-3
Molecular formula: C194H312N54O59S2
Molecular weight: 4409.07 g/mol
PubChem CID: —

Identity

CAS number: 1415456-99-3
Molecular formula: C194H312N54O59S2
Molecular weight: 4409.07 g/mol
Residues: 32

An engineered 32-residue sequence with non-natural substitutions, an intramolecular disulfide bridge, and a lipid side chain; a plain one-letter rendering would misstate it.

What it is

Cagrilintide is a synthetic analogue of human amylin (islet amyloid polypeptide), engineered for a long circulating half-life. The design combines residues drawn from human amylin and from salmon calcitonin with a lipid side chain attached through a linker.

It was described by Kruse and colleagues in 2021 under the development code AM833, and is studied in the literature as an agonist at the amylin and calcitonin receptors.

Regulatory status

Cagrilintide is an investigational compound. It is not an approved drug in any jurisdiction.

Primary literature

Kruse T, Hansen JL, Dahl K, et al. Development of Cagrilintide, a Long-Acting Amylin Analogue. Journal of Medicinal Chemistry 2021;64(15):11183–11194.
doi:10.1021/acs.jmedchem.1c00565

Citation titles are reproduced verbatim from the journal record. A citation documents the molecule's published identity and history; it is not a claim about the material sold here.

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