Synthetic hGH fragment analogue

AOD-9604

Also catalogued as AOD 9604, Tyr-hGH(177–191), hGH fragment 176–191 analogue.

CAS number: 221231-10-3
Molecular formula: C78H123N23O23S2
Molecular weight: 1815.08 g/mol
PubChem CID: —

Identity

CAS number: 221231-10-3
Molecular formula: C78H123N23O23S2
Molecular weight: 1815.08 g/mol
Residues: 16

Sequence: YLRIVQCRSVEGSCGF

What it is

AOD-9604 is a synthetic peptide corresponding to the carboxy-terminal fragment of human growth hormone, residues 176–191, with a tyrosine added at the amino terminus. The added tyrosine shifts the conventional numbering, which is why the same molecule appears in the literature and in supplier catalogues both as Tyr-hGH(177–191) and as an hGH fragment 176–191 analogue.

It contains the intramolecular disulfide bond of the parent fragment and is produced by chemical synthesis. It was developed at Monash University and characterised in the non-clinical literature from 2001.

Regulatory status

AOD-9604 is not an approved drug in any jurisdiction.

Primary literature

Heffernan MA, Summers RJ, Thorburn AW, et al. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. Endocrinology 2001;142(12):5182–5189.

Citation titles are reproduced verbatim from the journal record. A citation documents the molecule's published identity and history; it is not a claim about the material sold here.

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