Cyclic α-melanocyte-stimulating hormone analogue

PT-141

Also catalogued as Bremelanotide, PT141.

CAS number: 189691-06-3
Molecular formula: C50H68N14O10
Molecular weight: 1025.18 g/mol
PubChem CID: 9941379

Identity

CAS number: 189691-06-3
Molecular formula: C50H68N14O10
Molecular weight: 1025.18 g/mol
Residues: 7
PubChem CID: 9941379

Seven residues, written Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH. No one-letter string applies: norleucine and D-phenylalanine are not standard L-residues, and six of the seven are closed into a lactam ring rather than running end to end. The single difference from melanotan-2 is at the C-terminus, a free acid here in place of an amide, which is the one atom the two formulas differ by.

What it is

PT-141 is a cyclic seven-residue analogue of α-melanocyte-stimulating hormone and is the C-terminal deamidation product of melanotan-2 — the same acetylated norleucine and the same lactam-bridged ring, ending in a carboxylic acid instead of a primary amide.

It carries the development name bremelanotide and was described under that programme by Molinoff and colleagues in 2003. It is produced by chemical synthesis.

Regulatory status

Bremelanotide is an approved medicine in the United States under the brand name Vyleesi. Material supplied under this listing is a research chemical and is not that approved product.

Primary literature

Molinoff PB, Shadiack AM, Earle D, Diamond LE, Quon CY PT-141: a melanocortin agonist for the treatment of sexual dysfunction. Annals of the New York Academy of Sciences 2003;994:96–102.
PMID 12851303 doi:10.1111/j.1749-6632.2003.tb03167.x

Citation titles are reproduced verbatim from the journal record. A citation documents the molecule's published identity and history; it is not a claim about the material sold here.

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