Dinucleotide cofactor

NAD+

Also catalogued as Nicotinamide adenine dinucleotide, β-NAD, Coenzyme I, Diphosphopyridine nucleotide.

CAS number: 53-84-9
Molecular formula: C21H27N7O14P2
Molecular weight: 663.43 g/mol
PubChem CID: —

Identity

CAS number: 53-84-9
Molecular formula: C21H27N7O14P2
Molecular weight: 663.43 g/mol

What it is

NAD+ is nicotinamide adenine dinucleotide in its oxidised form: two nucleotides — one bearing nicotinamide, one bearing adenine — joined through their phosphate groups. It is not a peptide but a cofactor, present in every living cell, and it cycles between the oxidised (NAD+) and reduced (NADH) forms as it carries hydride between molecules.

It was first observed in 1906 by Harden and Young, who called the heat-stable factor they found in yeast extracts "cozymase". Warburg later identified the nicotinamide ring as the site of the redox chemistry. The listed material is the free acid or a salt of the oxidised form.

Regulatory status

NAD+ is a biochemical reagent. It is not an approved drug in any jurisdiction.

Primary literature

Belenky P, Bogan KL, Brenner C. NAD+ metabolism in health and disease. Trends in Biochemical Sciences 2007;32(1):12–19.
PMID 17161604

Citation titles are reproduced verbatim from the journal record. A citation documents the molecule's published identity and history; it is not a claim about the material sold here.

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