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For laboratory research use only. Not for human or veterinary use.
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Synthetic α-melanocyte-stimulating hormone analogue
Also catalogued as Afamelanotide, NDP-α-MSH, [Nle4, D-Phe7]-α-MSH, Melanotan I.
Thirteen residues, written Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2. No one-letter string is given because two positions are not standard L-amino acids: norleucine at position 4, in place of the methionine of α-MSH, and D-phenylalanine at position 7 in place of the L form. The ends are an N-terminal acetyl and a C-terminal amide.
Melanotan-1 is a synthetic linear analogue of α-melanocyte-stimulating hormone, the 13-residue peptide hormone cleaved from proopiomelanocortin. It differs from the natural hormone at exactly two positions: methionine at position 4 is replaced by norleucine, and the L-phenylalanine at position 7 is replaced by its D enantiomer. Both substitutions remove points at which the natural sequence is degraded.
The analogue was described by Sawyer and colleagues in 1980 at the University of Arizona and is the compound later developed under the name afamelanotide. It is produced by chemical synthesis.
Afamelanotide is an approved medicine in the United States and the European Union under the brand name Scenesse. Material supplied under this listing is a research chemical and is not that approved product.
Sawyer TK, Sanfilippo PJ, Hruby VJ, et al. 4-Norleucine, 7-D-phenylalanine-alpha-melanocyte-stimulating hormone: a highly potent alpha-melanotropin with ultralong biological activity. Proceedings of the National Academy of Sciences 1980;77(10):5754–5758.
Citation titles are reproduced verbatim from the journal record. A citation documents the molecule's published identity and history; it is not a claim about the material sold here.